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When NSAIDs were administered with aspirinthe protein binding of NSAIDs were reducedalthough the clearance of free NSAID was not alteredThe clinical significance of this interaction is not knownSee Table 2 for clinically significant drug interactions of NSAIDs with aspirinsee PRECAUTIONSDrug Interactions

Before having surgerytell your doctor or dentist that you are using this medication.

If you take Ponstelmefenamic acidon a regular basistake a missed dose as soon as you think about itIf it is close to the time for your next doseskip the missed dose and go back to your normal timeDo not take 2 doses at the same time or extra dosesMany times Ponstelmefenamic acidis taken on an as needed basisDo not take more often than told by the doctor.

NSAIDsincluding mefenamic acidcan cause serious skin adverse reactions such as exfoliative dermatitisStevens-Johnson SyndromeSJSand toxic epidermal necrolysisTENwhich can be fatalThese serious events may occur without warningInform patients about the signs and symptoms of serious skin reactions and to discontinue the use of Ponstel at the first appearance of skin rash or any other sign of hypersensitivityPonstel is contraindicated in patients with previous serious skin reactions to NSAIDssee CONTRAINDICATIONS

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