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A brief review of the HPA physiology may be helpful in understanding this rationaleActing primarily through the hypothalamus a fall in free cortisol stimulates the pituitary gland to produce increasing amounts of corticotropinACTHwhile a rise in free cortisol inhibits ACTH secretionNormally the HPA system is characterized by diurnalcircadianrhythmSerum levels of ACTH rise from a low point about 10 pm to a peak level about 6 amIncreasing levels of ACTH stimulate adrenocortical activity resulting in a rise in plasma cortisol with maximal levels occurring between 2 am and 8 amThis rise levitra 10mg discounts. in cortisol dampens ACTH production and in turn adrenocortical activityThere is a gradual fall in plasma corticoids during the day with lowest levels occurring about midnight.

Typical starting dosageThis may vary from 5 mg to 60 mg per daydepending on the condition being treatedFor immediate-release tablets onlyTo reduce side effectstwice the usual dose of this drug may be taken every other morningThis is called alternate day therapyDo not use alternate day therapy unless prescribed by your doctor.

Studies show a risk of adverse effects to the pregnancy when the mother takes the drugThis drug should only be used during pregnancy in serious cases where it’s needed to treat a dangerous condition in the mother.

Do not receive alivevaccine while using this medicinePrednisone may increase your risk of harmful effects from a live vaccineLive vaccines include measlesmumpsrubellaMMRrotavirustyphoidyellow fevervaricellachickenpoxzostershinglesand nasal fluinfluenzavaccine.

For palliative management ofleukemias and lymphomas in adultsacute leukemia of childhood.

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because fludrocortisone is synthetic, it is treated by the body as an invasive molecule, which induces many of the same side effects that occur with prednisone.

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